{"id":4891,"date":"2025-02-08T14:35:45","date_gmt":"2025-02-08T14:35:45","guid":{"rendered":"https:\/\/biovanix.com\/?page_id=4891"},"modified":"2025-02-08T15:05:47","modified_gmt":"2025-02-08T15:05:47","slug":"resina-cromatografica-inertshell-core-shell","status":"publish","type":"page","link":"https:\/\/biovanix.com\/es\/resina-cromatografica-inertshell-core-shell\/","title":{"rendered":"Resina de cromatograf\u00eda InertShell Core-Shell"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"4891\" class=\"elementor elementor-4891\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-69b69b3 e-flex e-con-boxed e-con e-parent\" data-id=\"69b69b3\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0e3b60c elementor-widget elementor-widget-heading\" data-id=\"0e3b60c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Resina de cromatograf\u00eda InertShell Core-Shell<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3719c7 elementor-widget elementor-widget-heading\" data-id=\"a3719c7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Para la purificaci\u00f3n de Adenoviridae ADV<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f0b1e72 elementor-widget elementor-widget-text-editor\" data-id=\"f0b1e72\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Resina de cromatograf\u00eda Biovanix InertShell<\/strong>\u00a0es una revolucionaria resina basada en la tecnolog\u00eda core-shell dise\u00f1ada para la purificaci\u00f3n de virus y biomol\u00e9culas de gran tama\u00f1o. Combinando la separaci\u00f3n por exclusi\u00f3n por tama\u00f1o con la cromatograf\u00eda de uni\u00f3n, esta avanzada resina captura y a\u00edsla eficazmente biomol\u00e9culas de gran tama\u00f1o, al tiempo que permite que los contaminantes m\u00e1s peque\u00f1os pasen a trav\u00e9s del n\u00facleo y se unan a \u00e9l. Esta doble funcionalidad garantiza resultados de gran pureza en el procesamiento posterior.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f7c01ae e-flex e-con-boxed e-con e-parent\" data-id=\"f7c01ae\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f50a5e8 elementor-widget elementor-widget-text-editor\" data-id=\"f50a5e8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Caracter\u00edsticas<\/h2><h4><strong>1. Tecnolog\u00eda Core-Shell<\/strong><\/h4><ul><li><strong>Doble funcionalidad:<\/strong>\u00a0Realiza simult\u00e1neamente la separaci\u00f3n por exclusi\u00f3n de tama\u00f1o y la cromatograf\u00eda de uni\u00f3n.<\/li><li><strong>Separaci\u00f3n eficaz:<\/strong>\u00a0Las biomol\u00e9culas grandes (por ejemplo, virus inactivados) se recogen en la fracci\u00f3n de flujo continuo (modo FT), mientras que los contaminantes (&lt;700 kDa) se unen a los ligandos internos.<\/li><li><strong>Dise\u00f1o optimizado:<\/strong>\u00a0La cubierta exterior es hidr\u00f3fila y neutra, lo que evita interacciones no deseadas y garantiza elevados caudales.<\/li><\/ul><h4><strong>2. Composici\u00f3n avanzada de materiales<\/strong><\/h4><ul><li><strong>Base de pol\u00edmero:<\/strong>\u00a0Fabricado con microesferas de metacrilato polim\u00e9rico para una mayor durabilidad y estabilidad qu\u00edmica.<\/li><li><strong>Ligando activo:<\/strong>\u00a0El ligando de octilamina en el n\u00facleo proporciona capacidades tanto de intercambio ani\u00f3nico como de interacci\u00f3n hidrof\u00f3bica.<\/li><li><strong>Estructura porosa:<\/strong>\u00a0La c\u00e1scara tiene un tama\u00f1o de poro de 50-100 nm, mientras que el n\u00facleo oscila entre 200-500 nm, lo que garantiza una separaci\u00f3n eficaz en funci\u00f3n del tama\u00f1o molecular.<\/li><\/ul><h4><strong>3. Alta pureza y eficacia<\/strong><\/h4><ul><li><strong>Captura selectiva:<\/strong>\u00a0Elimina eficazmente impurezas como prote\u00ednas de c\u00e9lulas hu\u00e9sped, fragmentos de ADN, endotoxinas y alb\u00famina.<\/li><li><strong>Alta capacidad:<\/strong>\u00a0Dise\u00f1ada para gestionar procesos de purificaci\u00f3n a gran escala con gran eficacia y escalabilidad.<\/li><\/ul><h4><strong>4. Cumplimiento y seguridad<\/strong><\/h4><ul><li><strong>Derivado no animal:<\/strong>\u00a0fabricados mediante procesos sint\u00e9ticos, garantizando el cumplimiento de las normas reglamentarias y los requisitos \u00e9ticos.<\/li><li><strong>Rendimiento estable:<\/strong>\u00a0Fiabilidad en varias escalas de producci\u00f3n, lo que garantiza resultados uniformes.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a3ef2f9 e-flex e-con-boxed e-con e-parent\" data-id=\"a3ef2f9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9980b74 elementor-widget elementor-widget-text-editor\" data-id=\"9980b74\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"fl-row fl-row-fixed-width fl-row-bg-color fl-node-60f5336b77e5a fl-row-default-height fl-row-align-center nitro-offscreen\" data-node=\"60f5336b77e5a\"><div class=\"fl-row-content-wrap\"><div class=\"fl-row-content fl-row-fixed-width fl-node-content\"><div class=\"fl-col-group fl-node-60f5336b7a7d0\" data-node=\"60f5336b7a7d0\"><div class=\"fl-col fl-node-60f5336b7a866 fl-col-bg-color\" data-node=\"60f5336b7a866\"><div class=\"fl-col-content fl-node-content\"><div class=\"fl-module fl-module-rich-text fl-node-60f5336b77c2b\" data-node=\"60f5336b77c2b\"><div class=\"fl-module-content fl-node-content\"><div class=\"fl-rich-text\"><h2><strong>Especificaci\u00f3n<\/strong><\/h2><table><tbody><tr><td width=\"229\">\u00a0<\/td><td width=\"233\"><strong>Carcasa inerte Biovanix<\/strong><\/td><td width=\"203\"><strong>Competidor 700<\/strong><\/td><\/tr><tr><td width=\"229\">Matriz<\/td><td width=\"233\">Poliacrilato<\/td><td width=\"203\">Agarosa altamente reticulada<\/td><\/tr><tr><td width=\"229\">Ligando<\/td><td width=\"233\">Octilamina<\/td><td width=\"203\">Octilamina<\/td><\/tr><tr><td width=\"229\">Tama\u00f1o medio de las part\u00edculas<\/td><td width=\"233\">50-150 \u03bcm<\/td><td width=\"203\">50-150 \u03bcm<\/td><\/tr><tr><td width=\"229\">Densidad del ligando<\/td><td width=\"233\">0,10-0,20 mmol\/mL<\/td><td width=\"203\">0,04-0,085 mmol\/mL<\/td><\/tr><tr><td width=\"229\">Capacidad de encuadernaci\u00f3n\u00b9<\/td><td width=\"233\">20 mg BSA\/mL resina<\/td><td width=\"203\">12 mg BSA\/mL resina<\/td><\/tr><tr><td width=\"229\">Presi\u00f3n operativa<\/td><td width=\"233\">\u22641,0 MPa<\/td><td width=\"203\">\u22640,3 MPa<\/td><\/tr><tr><td width=\"229\">Caudal operativo<\/td><td width=\"233\">100-600 cm\/h<\/td><td width=\"203\">100-600 cm\/h<\/td><\/tr><tr><td width=\"229\">Estabilidad del pH<\/td><td width=\"233\">3-13<\/td><td width=\"203\">3-13<\/td><\/tr><tr><td width=\"229\">Temperatura<\/td><td width=\"233\">4-30\u2103<\/td><td width=\"203\">4-30\u2103<\/td><\/tr><tr><td width=\"229\">Estabilidad qu\u00edmica<\/td><td colspan=\"2\" width=\"435\">Todos los tampones acuosos utilizados habitualmente, hidr\u00f3xido de sodio (NaOH)\u00b2 1 M, clorhidrato de guanidina 6 M, isopropanol 30% y etanol 70%.<\/td><\/tr><tr><td width=\"229\">Almacenamiento<\/td><td colspan=\"2\" width=\"435\">20% etanol a 4\u00b0C a 25 \u2103.<\/td><\/tr><\/tbody><\/table><ol><li><em>Capacidad de uni\u00f3n din\u00e1mica medida a 5% de avance con 76 cm\/h en columnas de \u03c610\u00d713 mm, 1 mL. El tamp\u00f3n fue 1,0 mg\/mL BSA 50 mM NaCl, pH 0.<\/em><\/li><li><em>No se produjeron cambios significativos en la capacidad i\u00f3nica ni en el contenido de carbono tras un almacenamiento de 1 semana en NaOH 1 M a 25\u00b0C.<\/em><\/li><\/ol><p>En comparaci\u00f3n con Competitor 700, el grosor del n\u00facleo en Biovanix Inert Shell (0,5-1,0 \u03bcm) es menor que en Competitor 700 (5 \u03bcm). Biovanix Inert Shell favorece la r\u00e1pida transferencia de masa de prote\u00ednas impuras al n\u00facleo del medio para su captura, como prote\u00ednas celulares del hu\u00e9sped, fragmentos de ADN, endotoxina, suero. Biovanix Inert Shell tiene un mayor rendimiento en cantidad de prote\u00ednas diversas. Con la estructura macroporosa (200-500 nm) del n\u00facleo en Biovanix Inert Shell puede eliminar r\u00e1pidamente la prote\u00edna miscel\u00e1nea en CIP. Biovanix Inert Shell tambi\u00e9n tiene una vida \u00fatil m\u00e1s larga en el proceso de purificaci\u00f3n. En estudios de vacunas animales, el rendimiento de Biovnanix Inert Shell puede repetirse m\u00e1s de 30 veces con menos cambios en sus propiedades.<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3a8e876 e-flex e-con-boxed e-con e-parent\" data-id=\"3a8e876\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f56435 elementor-widget elementor-widget-text-editor\" data-id=\"7f56435\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><strong>Aplicaciones<\/strong><\/h2><h4><strong>Purificaci\u00f3n de virus<\/strong><\/h4><p>Aislamiento eficaz de virus inactivados para vacunas y terapias g\u00e9nicas.<\/p><h4><strong>Separaci\u00f3n de grandes biomol\u00e9culas<\/strong><\/h4><p>Adecuado para la purificaci\u00f3n de grandes prote\u00ednas y complejos.<\/p><h4><strong>Eliminaci\u00f3n de prote\u00ednas de la c\u00e9lula hu\u00e9sped<\/strong><\/h4><p>Eliminaci\u00f3n eficaz de las prote\u00ednas de las c\u00e9lulas hu\u00e9sped y otras impurezas.<\/p><h4><strong>Producci\u00f3n de vacunas<\/strong><\/h4><p>Racionalizaci\u00f3n del procesamiento posterior para vacunas de ARNm y vacunas basadas en vectores virales.<\/p><h4><strong>Terapia g\u00e9nica<\/strong><\/h4><p>Producci\u00f3n escalable de vectores virales para aplicaciones de terapia g\u00e9nica.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0c5859e e-flex e-con-boxed e-con e-parent\" data-id=\"0c5859e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-495b56b elementor-widget elementor-widget-text-editor\" data-id=\"495b56b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><strong>\u00bfPor qu\u00e9 elegir la resina de cromatograf\u00eda Biovanix InertShell?<\/strong><\/h2><h4><strong>Pureza mejorada<\/strong><\/h4><p>Eliminaci\u00f3n eficaz de impurezas para lograr una pureza ultraelevada en la purificaci\u00f3n de virus y biomol\u00e9culas.<\/p><h4><strong>Funcionamiento en modo dual<\/strong><\/h4><p>Combina la cromatograf\u00eda de exclusi\u00f3n por tama\u00f1o y de uni\u00f3n para un control vers\u00e1til y preciso.<\/p><h4><strong>Soluci\u00f3n escalable<\/strong><\/h4><p>Ideal tanto para procesos de fabricaci\u00f3n a escala de laboratorio como a gran escala.<\/p><h4><strong>Rentable<\/strong><\/h4><p>Los flujos de proceso simplificados y la alta eficiencia reducen los costes operativos y mejoran la productividad.<\/p><h4><strong>Cumplimiento de la normativa<\/strong><\/h4><p>La fabricaci\u00f3n sint\u00e9tica y sin animales garantiza el cumplimiento de las normas biofarmac\u00e9uticas mundiales.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-765321d e-flex e-con-boxed e-con e-parent\" data-id=\"765321d\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c6f438a elementor-widget elementor-widget-heading\" data-id=\"c6f438a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Testimonio de un cliente<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9237c24 elementor-widget elementor-widget-text-editor\" data-id=\"9237c24\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>\"La resina de afinidad Biovanix Oligo dT(25) ha revolucionado nuestro proceso de purificaci\u00f3n de ARNm. La alta selectividad y capacidad de la resina han mejorado significativamente nuestro rendimiento y pureza, permiti\u00e9ndonos satisfacer la creciente demanda de vacunas de ARNm.\"<\/em><br \/>-\u00a0<strong>John, Ingeniero de Bioprocesos, A Biopharma<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>InertShell Core-Shell Chromatography Resin For Adenoviridae ADV Purification Biovanix InertShell Chromatography Resin\u00a0is a revolutionary core-shell technology-based resin designed for the purification of viruses and large biomolecules. Combining size-exclusion separation with binding chromatography, this advanced resin efficiently captures and isolates large biomolecules while allowing smaller contaminants to pass through and bind within the core. This dual [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-4891","page","type-page","status-publish","hentry"],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"trp-custom-language-flag":false,"woocommerce_thumbnail":false,"woocommerce_single":false,"woocommerce_gallery_thumbnail":false},"uagb_author_info":{"display_name":"biovanix.com","author_link":"https:\/\/biovanix.com\/es\/author\/biovanix-com\/"},"uagb_comment_info":0,"uagb_excerpt":"InertShell Core-Shell Chromatography Resin For Adenoviridae ADV Purification Biovanix InertShell Chromatography Resin\u00a0is a revolutionary core-shell technology-based resin designed for the purification of viruses and large biomolecules. Combining size-exclusion separation with binding chromatography, this advanced resin efficiently captures and isolates large biomolecules while allowing smaller contaminants to pass through and bind within the core. This dual&hellip;","aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.9.3 - aioseo.com -->\n\t<meta name=\"description\" content=\"Biovanix InertShell Chromatography Resin is designed with core-shell technology where the beads are designed and optimized for the purification of viruses and other large biomolecules.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/biovanix.com\/es\/resina-cromatografica-inertshell-core-shell\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO Pro (AIOSEO) 4.9.3\" \/>\n\t\t<meta property=\"og:locale\" content=\"es_ES\" \/>\n\t\t<meta property=\"og:site_name\" content=\"BioVanix | Professional Instrument Supplier\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"InertShell Core-Shell Chromatography Resin | BioVanix\" \/>\n\t\t<meta property=\"og:description\" content=\"Biovanix InertShell Chromatography Resin is designed with 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