{"id":4891,"date":"2025-02-08T14:35:45","date_gmt":"2025-02-08T14:35:45","guid":{"rendered":"https:\/\/biovanix.com\/?page_id=4891"},"modified":"2025-02-08T15:05:47","modified_gmt":"2025-02-08T15:05:47","slug":"inertshell-core-shell-chromatography-resin","status":"publish","type":"page","link":"https:\/\/biovanix.com\/fr\/inertshell-core-shell-chromatography-resin\/","title":{"rendered":"R\u00e9sine de chromatographie InertShell Core-Shell"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"4891\" class=\"elementor elementor-4891\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-69b69b3 e-flex e-con-boxed e-con e-parent\" data-id=\"69b69b3\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0e3b60c elementor-widget elementor-widget-heading\" data-id=\"0e3b60c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">R\u00e9sine de chromatographie InertShell Core-Shell<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3719c7 elementor-widget elementor-widget-heading\" data-id=\"a3719c7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">For Adenoviridae ADV Purification<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f0b1e72 elementor-widget elementor-widget-text-editor\" data-id=\"f0b1e72\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Biovanix InertShell Chromatography Resin<\/strong>\u00a0is a revolutionary core-shell technology-based resin designed for the purification of viruses and large biomolecules. Combining size-exclusion separation with binding chromatography, this advanced resin efficiently captures and isolates large biomolecules while allowing smaller contaminants to pass through and bind within the core. This dual functionality ensures high-purity outcomes in downstream processing.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f7c01ae e-flex e-con-boxed e-con e-parent\" data-id=\"f7c01ae\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f50a5e8 elementor-widget elementor-widget-text-editor\" data-id=\"f50a5e8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Features<\/h2><h4><strong>1. Core-Shell Technology<\/strong><\/h4><ul><li><strong>Dual Functionality:<\/strong>\u00a0Simultaneously performs size-exclusion separation and binding chromatography.<\/li><li><strong>Efficient Separation:<\/strong>\u00a0Large biomolecules (e.g., inactivated viruses) are collected in the flow-through fraction (FT mode), while contaminants (&lt;700 kDa) bind to the internal ligands.<\/li><li><strong>Optimized Design:<\/strong>\u00a0The outer shell is hydrophilic and neutral, preventing unwanted interactions and ensuring high flow rates.<\/li><\/ul><h4><strong>2. Advanced Material Composition<\/strong><\/h4><ul><li><strong>Polymer Base:<\/strong>\u00a0Made of polymeric methacrylate microspheres for robust durability and chemical stability.<\/li><li><strong>Active Ligand:<\/strong>\u00a0Octylamine ligand in the core provides both anion exchange and hydrophobic interaction capabilities.<\/li><li><strong>Porous Structure:<\/strong>\u00a0The shell has a pore size of 50-100 nm, while the core ranges from 200-500 nm, ensuring efficient separation based on molecular size.<\/li><\/ul><h4><strong>3. High Purity and Efficiency<\/strong><\/h4><ul><li><strong>Selective Capture:<\/strong>\u00a0Effectively removes impurities such as host cell proteins, DNA fragments, endotoxins, and albumin.<\/li><li><strong>High Capacity:<\/strong>\u00a0Designed to handle large-scale purification processes with high efficiency and scalability.<\/li><\/ul><h4><strong>4. Compliance and Safety<\/strong><\/h4><ul><li><strong>Non-Animal Derived:<\/strong>\u00a0manufactured using synthetic processes, ensuring compliance with regulatory standards and ethical requirements.<\/li><li><strong>Stable Performance:<\/strong>\u00a0Reliable across various production scales, ensuring consistent results.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a3ef2f9 e-flex e-con-boxed e-con e-parent\" data-id=\"a3ef2f9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9980b74 elementor-widget elementor-widget-text-editor\" data-id=\"9980b74\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"fl-row fl-row-fixed-width fl-row-bg-color fl-node-60f5336b77e5a fl-row-default-height fl-row-align-center nitro-offscreen\" data-node=\"60f5336b77e5a\"><div class=\"fl-row-content-wrap\"><div class=\"fl-row-content fl-row-fixed-width fl-node-content\"><div class=\"fl-col-group fl-node-60f5336b7a7d0\" data-node=\"60f5336b7a7d0\"><div class=\"fl-col fl-node-60f5336b7a866 fl-col-bg-color\" data-node=\"60f5336b7a866\"><div class=\"fl-col-content fl-node-content\"><div class=\"fl-module fl-module-rich-text fl-node-60f5336b77c2b\" data-node=\"60f5336b77c2b\"><div class=\"fl-module-content fl-node-content\"><div class=\"fl-rich-text\"><h2><strong>Specification<\/strong><\/h2><table><tbody><tr><td width=\"229\">\u00a0<\/td><td width=\"233\"><strong>Biovanix Inert Shell<\/strong><\/td><td width=\"203\"><strong>Competitor 700<\/strong><\/td><\/tr><tr><td width=\"229\">Matrice<\/td><td width=\"233\">Polyacrylate<\/td><td width=\"203\">Highly cross\u2011linked agarose<\/td><\/tr><tr><td width=\"229\">Ligand<\/td><td width=\"233\">Octylamine<\/td><td width=\"203\">Octylamine<\/td><\/tr><tr><td width=\"229\">Average particle size<\/td><td width=\"233\">50-150 \u03bcm<\/td><td width=\"203\">50-150 \u03bcm<\/td><\/tr><tr><td width=\"229\">Density of ligand<\/td><td width=\"233\">0.10-0.20 mmol\/mL<\/td><td width=\"203\">0.04-0.085 mmol\/mL<\/td><\/tr><tr><td width=\"229\">Binding capacity\u00b9<\/td><td width=\"233\">20 mg BSA\/mL resin<\/td><td width=\"203\">12 mg BSA\/mL resin<\/td><\/tr><tr><td width=\"229\">Operational pressure<\/td><td width=\"233\">\u22641.0 MPa<\/td><td width=\"203\">\u22640.3 MPa<\/td><\/tr><tr><td width=\"229\">Operational flow rate<\/td><td width=\"233\">100-600 cm\/h<\/td><td width=\"203\">100-600 cm\/h<\/td><\/tr><tr><td width=\"229\">pH stability<\/td><td width=\"233\">3-13<\/td><td width=\"203\">3-13<\/td><\/tr><tr><td width=\"229\">Temperature<\/td><td width=\"233\">4-30\u2103<\/td><td width=\"203\">4-30\u2103<\/td><\/tr><tr><td width=\"229\">Chemical stability<\/td><td colspan=\"2\" width=\"435\">All commonly used aqueous buffers, 1 M sodium hydroxide (NaOH)\u00b2, 6 M guanidine hydrochloride, 30% isopropanol, and 70% ethanol.<\/td><\/tr><tr><td width=\"229\">Stockage<\/td><td colspan=\"2\" width=\"435\">20% ethanol at 4\u00b0C to 25 \u2103<\/td><\/tr><\/tbody><\/table><ol><li><em>Dynamic binding capacity measured at 5% breakthrough with 76 cm\/h on \u03c610\u00d713 mm, 1 mL columns. The buffer was 1.0 mg\/mL BSA 50 mM NaCl, pH 0.<\/em><\/li><li><em>No significant changes in ionic capacity and carbon content after storage 1 week in 1 M NaOH at 25\u00b0C.<\/em><\/li><\/ol><p>Compared with Competitor 700, the thickness of the core in Biovanix Inert Shell (0.5-1.0 \u03bcm) is smaller than Competitor 700 (5 \u03bcm). Biovanix Inert Shell is conducive to the rapid mass transfer of impure proteins to the medium core for capture, like cell proteins of the host, DNA fragments, endotoxin, serum. Biovanix Inert Shell has a higher yield amount of miscellaneous protein. With the macroporous structure (200-500 nm) of the core in Biovanix Inert Shell can quickly remove the miscellaneous protein in CIP. Biovanix Inert Shell also has a longer service life in the purification process. In animal vaccine studies, the performance of Biovnanix Inert Shell can be repeated use more than 30 times with less change in its properties.<\/p><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3a8e876 e-flex e-con-boxed e-con e-parent\" data-id=\"3a8e876\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f56435 elementor-widget elementor-widget-text-editor\" data-id=\"7f56435\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><strong>Applications<\/strong><\/h2><h4><strong>Virus Purification<\/strong><\/h4><p>Effective isolation of inactivated viruses for vaccines and gene therapies.<\/p><h4><strong>Large Biomolecule Separation<\/strong><\/h4><p>Suitable for the purification of large proteins and complexes.<\/p><h4><strong>Host Cell Protein Removal<\/strong><\/h4><p>Efficient elimination of host cell proteins and other impurities.<\/p><h4><strong>Vaccine Production<\/strong><\/h4><p>Streamlined downstream processing for mRNA vaccines and viral vector-based vaccines.<\/p><h4><strong>Gene Therapy<\/strong><\/h4><p>Scalable production of viral vectors for gene therapy applications.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0c5859e e-flex e-con-boxed e-con e-parent\" data-id=\"0c5859e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-495b56b elementor-widget elementor-widget-text-editor\" data-id=\"495b56b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><strong>Why Choose Biovanix InertShell Chromatography Resin?<\/strong><\/h2><h4><strong>Enhanced Purity<\/strong><\/h4><p>Efficient removal of impurities to achieve ultra-high purity in virus and biomolecule purification.<\/p><h4><strong>Dual Mode Operation<\/strong><\/h4><p>Combines size-exclusion and binding chromatography for versatile and precise control.<\/p><h4><strong>Scalable Solution<\/strong><\/h4><p>Ideal for both lab-scale and large-scale manufacturing processes.<\/p><h4><strong>Cost-Effective<\/strong><\/h4><p>Simplified process flows and high efficiency reduce operational costs and improve productivity.<\/p><h4><strong>Conformit\u00e9 r\u00e9glementaire<\/strong><\/h4><p>Non-animal derived and synthetic manufacturing ensure adherence to global biopharmaceutical standards.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-765321d e-flex e-con-boxed e-con e-parent\" data-id=\"765321d\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c6f438a elementor-widget elementor-widget-heading\" data-id=\"c6f438a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Customer Testimonial<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9237c24 elementor-widget elementor-widget-text-editor\" data-id=\"9237c24\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>&#8220;Biovanix Oligo dT(25) Affinity Resin has revolutionized our mRNA purification process. The resin&#8217;s high selectivity and capacity have significantly improved our yield and purity, enabling us to meet the growing demand for mRNA vaccines.&#8221;<\/em><br \/>\u2013\u00a0<strong>John, Bioprocess Engineer, A Biopharma<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>InertShell Core-Shell Chromatography Resin For Adenoviridae ADV Purification Biovanix InertShell Chromatography Resin\u00a0is a revolutionary core-shell technology-based resin designed for the purification of viruses and large biomolecules. Combining size-exclusion separation with binding chromatography, this advanced resin efficiently captures and isolates large biomolecules while allowing smaller contaminants to pass through and bind within the core. This dual [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-4891","page","type-page","status-publish","hentry"],"aioseo_notices":[],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"trp-custom-language-flag":false,"woocommerce_thumbnail":false,"woocommerce_single":false,"woocommerce_gallery_thumbnail":false},"uagb_author_info":{"display_name":"biovanix.com","author_link":"https:\/\/biovanix.com\/fr\/author\/biovanix-com\/"},"uagb_comment_info":0,"uagb_excerpt":"InertShell Core-Shell Chromatography Resin For Adenoviridae ADV Purification Biovanix InertShell Chromatography Resin\u00a0is a revolutionary core-shell technology-based resin designed for the purification of viruses and large biomolecules. Combining size-exclusion separation with binding chromatography, this advanced resin efficiently captures and isolates large biomolecules while allowing smaller contaminants to pass through and bind within the core. This dual\u2026","aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.9.3 - aioseo.com -->\n\t<meta name=\"description\" content=\"Biovanix InertShell Chromatography Resin is designed with core-shell technology where the beads are designed and optimized for the purification of viruses and other large biomolecules.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<link rel=\"canonical\" href=\"https:\/\/biovanix.com\/fr\/inertshell-core-shell-chromatography-resin\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO Pro (AIOSEO) 4.9.3\" \/>\n\t\t<meta property=\"og:locale\" content=\"fr_FR\" \/>\n\t\t<meta property=\"og:site_name\" content=\"BioVanix | Professional Instrument Supplier\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"InertShell Core-Shell Chromatography Resin | BioVanix\" \/>\n\t\t<meta property=\"og:description\" content=\"Biovanix InertShell Chromatography Resin is designed with 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