{"id":5099,"date":"2025-02-27T12:56:35","date_gmt":"2025-02-27T12:56:35","guid":{"rendered":"https:\/\/biovanix.com\/?page_id=5099"},"modified":"2026-09-15T12:11:59","modified_gmt":"2026-09-15T04:11:59","slug":"resine-de-chromatographie-a-perfusion-biopure-af","status":"publish","type":"page","link":"https:\/\/biovanix.com\/fr\/biopure-af-perfusion-chromatography-resin\/","title":{"rendered":"R\u00e9sine de chromatographie \u00e0 perfusion Biopure AF"},"content":{"rendered":"
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R\u00e9sine de chromatographie \u00e0 perfusion Biopure AF<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Biovanix Biopure AF is a rigid, hydrophilic PS-DVB perfusion chromatography resin with 3000\u20136000\u00c5 throughpores and flexible tentacle ligands \u2014 designed for high-flow capture of capsular viruses at 1000\u00a0cm\/h with 100\u00a0mg\/ml dynamic binding capacity.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t<\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\tProduct Specification<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u221a 3000\u20136000\u00c5 Throughpores<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\u221a 100 mg\/ml DBC at High Flow<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\u221a pH 1\u201314 Stability<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\u221a 2\u20133\u00d7 Throughput vs. Fast-flow Gels<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\u221a Tentacle Ligand Technolog<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Biopure AF Resin at a Glance<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Key specifications for process-scale viral purification chromatography.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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PS\/DVB<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Substrat<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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70 \u00b5m<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Taille des particules<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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3000\u20136000\u00c5<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Taille des pores<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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100 mg\/ml<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Capacit\u00e9 de liaison dynamique<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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1000 cm\/h<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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D\u00e9bit maximum<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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1\u201314<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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pH Stability Range<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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20\u201340 cm<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Hauteur du lit de la colonne<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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4\u201330\u00b0C<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Temp\u00e9rature de fonctionnement<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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0.5\u20131M NaOH<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Condition CIP<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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2\u20138\u00b0C<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Storage Temperature<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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High-Performance Perfusion Chromatography Media<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Combining innovative bonding and surface treatment techniques, Biovanix developed a series of high-performance Biopure perfusion chromatography resins. Biopure is hydrophilic porous polymer microspheres developed based on PSDVB microspheres with extremely low non-specific adsorption. Biopure media are top-performing chromatographic media for process-scale bioseparations. The rigid, robust particles enable high-resolution separations with 2\u20133\u00d7 the throughput of conventional fast-flow gels. They are easier to handle and pack and offer outstanding cleanability.<\/p>

Les milieux de chromatographie par perfusion de Biopure offrent de meilleurs choix pour vos processus de purification dans les domaines des sciences biologiques, du g\u00e9nie biologique et de l'industrie pharmaceutique.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Biopure AF Media Advantages<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Engineered for efficiency, safety, and scalability in biopharmaceutical virus purification.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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High Selectivity<\/h3>

Similar affinity to live and inactivated capsular viruses, enabling consistent capture across different virus states.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Closed, Safe, and Sterile<\/h3>

Closed-column operation ensures safety and sterility throughout the entire purification process.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Streamlined Process<\/h3>

Enrichment and purification are carried out simultaneously, increasing production while reducing processing steps, time, and cost.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Rigid Particles, High Flow Rate<\/h3>

Rigid particles can be operated under a high flow rate, significantly improving purification efficiency.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Excellent Chemical Stability<\/h3>

Good chemical stability delivers longer service life, reducing resin replacement frequency and operational cost.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Need help selecting the right resin for your virus purification process?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tContact Our Team<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Core Technology Features<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Innovative particle engineering that sets Biopure AF apart in perfusion chromatography.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Polyvalence<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Multiple Choices<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Supports interactifs d'\u00e9change d'ions, d'affinit\u00e9 et hydrophobes. Choix multiples pour diff\u00e9rentes applications.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"Three-step\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Particle Design<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Microsph\u00e8re rigide avec des pores de grande taille<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The core of VirCap\u00ae particles is the novel porous structure with large “throughpores”. These large throughpores allow part of mobile phase flow through, quickly carrying biomolecules to smaller diffusive pores. The large “throughpores” reduce diffusion rate of biomolecules and enhance interaction between biomolecules and functional groups on the surface. Consequently, diffusion barriers are lowered, and flow rate can be dramatically increased \u2014 without compromising capacity or resolution.<\/p>

\u221a 3000\u20136000\u00c5 pore size, enable the diffusion and mass transfer for large biomolecules.<\/p>

\u221a 45\u201390 micron particles, satisfy your purification processing requests.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Ligand Architecture<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Tentacules flexibles<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Flexible tentacle structure minimizes the steric hindrance between functional groups and target molecules. It also improves the binding capability of the target material. Compared to traditional media, VirCap\u00ae media have more effective capture and higher total recovery.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"Stylized\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Performance<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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D\u00e9bit \u00e9lev\u00e9, faible contre-pression<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Biopure media offer an excellent balance of resolution and operating backpressure. Under the condition of mobile phase change, VirCap\u00ae media exhibits almost no shrinkage or expansion. Throughpores and flexible tentacles ensures the rapid diffusion of solute, reduces the barrier of mass transfer, and realizes the high dynamic load under the operation of high flow rate.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Durabilit\u00e9<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Durability\nRobust Chemical Stability<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Les milieux Biopure sont des particules polym\u00e8res rigides recouvertes d'un polym\u00e8re hydrophile exclusif sur lequel les diff\u00e9rents groupes fonctionnels (\u00e9change d'ions, affinit\u00e9, etc.) sont attach\u00e9s de mani\u00e8re covalente. Il en r\u00e9sulte un produit tr\u00e8s robuste et chimiquement stable, parfaitement adapt\u00e9 aux applications biopharmaceutiques \u00e0 grande \u00e9chelle.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Maintenance<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Condition de nettoyage en place (CIP)<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Biopure AF supports robust cleaning-in-place protocols to ensure column hygiene and consistent performance across multiple cycles.<\/p>

\u221a 0.5\u20131M NaOH<\/p>

\u221a Organic solvent<\/p>

\u221a High salt solvent<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Biopure AF Resin Parameters<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Complete technical specifications for process development and scale-up.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Biopure AF Perfusion Chromatography Resin \u2014 Technical Data Sheet<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Substrat<\/strong><\/td>Microsph\u00e8res hydrophiles PS\/DVB<\/td><\/tr>
Taille des particules<\/strong><\/td>70um<\/td><\/tr>
Capacit\u00e9 de liaison dynamique<\/strong><\/td>100 mg de lysozyme\/ml<\/td><\/tr>
D\u00e9bit<\/strong><\/td>

1000cm\/h (20\u2103, viscosit\u00e9 de la solution tampon identique \u00e0 celle de l'eau\uff0cpression < 3 bar \/ 43,5psi, hauteur du lit de la colonne 20cm).<\/p><\/td><\/tr>

Hauteur du lit de la colonne<\/strong><\/td>20-40cm<\/td><\/tr>
Stabilit\u00e9 du pH<\/strong><\/td>1-14<\/td><\/tr>
Temp\u00e9rature de fonctionnement<\/strong><\/td>4-30\u2103<\/td><\/tr>
Condition CIP<\/strong><\/td>0,5-1M NaOH<\/td><\/tr>
Stockage<\/strong><\/td>2-8\u2103 20% EtOH<\/td><\/tr><\/tbody><\/table><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Virus & Antigen Applications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Biopure AF resin has been successfully applied to purify a broad range of capsular viruses and viral\/microbial antigens.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Validated Virus and Antigen Applications for Biopure AF Perfusion Chromatography Resin<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Virus<\/b><\/td>Antig\u00e8nes viraux\/microbiens<\/b><\/td><\/tr>
Rage<\/td>Calicivirus f\u00e9lin<\/td>Sous-unit\u00e9s des glycoprot\u00e9ines gA et gB de l'herp\u00e8s simplex<\/td><\/tr>
Grippe<\/td>Virus respiratoire syncytial<\/td>Antig\u00e8ne de surface de l'h\u00e9patite B<\/td><\/tr>
Enc\u00e9phalite japonaise<\/td>Herp\u00e8s simplex humain<\/td>H\u00e9magglutinine filamenteuse de B. pertussis<\/td><\/tr>
Leuc\u00e9mie f\u00e9line<\/td>Rougeole humaine<\/td>Facteur de promotion de la leucocytose H\u00e9magglutinine<\/td><\/tr>
Herp\u00e8s f\u00e9lin<\/td>Parainfluenza humaine<\/td>\u00a0<\/td><\/tr><\/tbody><\/table><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Test de purification des r\u00e9coltes de virus de la rage (vaccin antirabique) \u00e0 l'aide du milieu de chromatographie par perfusion de Biopure, visitez ici >>.<\/strong><\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Why Perfusion Chromatography for Virus Purification?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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La purification des virus est la base du d\u00e9veloppement de vaccins de haute qualit\u00e9 et fournit \u00e9galement une base importante pour l'\u00e9tude de la structure morphologique fine du virus, l'isolement et la purification de la prot\u00e9ine antig\u00e8ne du virus, ainsi que des \u00e9tudes d\u00e9taill\u00e9es de la composition chimique et du mat\u00e9riel g\u00e9n\u00e9tique du virus.<\/p>

Le processus de purification ultrarapide par gradient de densit\u00e9 de saccharose utilis\u00e9 dans les proc\u00e9d\u00e9s traditionnels de purification des vaccins antiviraux n\u00e9cessite de grands appareils centrifuges tr\u00e8s co\u00fbteux. Ces appareils ont une faible charge d'\u00e9chantillon, des temps de traitement longs et une mauvaise \u00e9limination de l'ADN de la cellule h\u00f4te. La chromatographie par filtration sur gel, largement utilis\u00e9e dans le processus de purification des vaccins, est douce, reproductible et facile \u00e0 industrialiser. Cependant, son efficacit\u00e9 est faible et l'effet de l'\u00e9limination des h\u00e9t\u00e9roprot\u00e9ines et de l'ADN n'est pas \u00e9vident.<\/p>

VirCap\u00ae AF media is an affinity chromatography media designed to capture and moderate capsular virus purification stages. Specific adsorption of VirCap\u00ae AF media and target occurs by simulating the affinity between ligands and virus particles with capsular membranes. With unique high loading capacity, high flow rate and low back pressure, VirCap\u00ae AF media reduces the process cycle time and increases the yield, fully meeting the requirements of large-scale biopharmaceutical and vaccine production processes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Particle Microstructure & Ligand Bonding Technology<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Particle SEM Picture \u2014 Biopure AF porous microsphere morphology<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Technologie de liaison des ligands<\/h3>

Functional groups or ligand on traditional packing materials are distributed along their surface. This limits their ability to effectively interact with bio-molecules. GALAK developed technologies to build “tentacle structure” on its ion-exchange and affinity packing materials. Flexible tentacle structures minimize the steric hindrance between functional groups or ligand and target molecules, improving the binding capability of the target molecules. Compared to traditional packing materials, GALAK’s PS-DVB particles show more effective capture and higher recovery.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Application Scenarios<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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From vaccine development to structural virology \u2014 Biopure AF supports every stage of your purification workflow.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Vaccine Purification<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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High-quality vaccine development requires efficient, scalable virus capture. Biopure AF delivers one-step enrichment and purification for live and inactivated virus vaccines.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Virus Morphological Studies<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Provides purified virus particles suitable for fine morphological structure analysis using electron microscopy and other advanced imaging techniques.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Antigen Protein Isolation<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Isolation and purification of viral antigen proteins for downstream characterization, formulation, and quality control in biopharmaceutical manufacturing.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Genetic Material Research<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Obtain highly pure virus preparations for detailed studies of viral chemical composition and genetic material, supporting genomic and proteomic analysis.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Ready to optimize your virus purification workflow?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tGet Technical Support<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Related Products & Complementary Solutions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Build a complete purification workflow with Biovanix resins, columns, and systems.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Chromatography Resins & Media<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Resin Family<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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R\u00e9sine Core-Shell InertShell<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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PMMA core-shell technology designed for inactivated virus flow-through purification. Complements Biopure AF in a capture-and-polish workflow.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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View Product \u2192<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Supermacroporous Polymer Microspheres<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Ultra-large pore polymer microspheres delivering 10\u00d7 binding capacity for challenging separations of very large biomolecules and viruses.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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View Product \u2192<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Supports de chromatographie PSDVB<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Polystyrene-divinylbenzene-based chromatography media with customizable pore sizes from 100 nm to 400 nm for diverse separation needs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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View Product \u2192<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Supports de chromatographie en PMMA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Polymethyl methacrylate-based media offering excellent biocompatibility and tailored surface chemistry for specific purification applications.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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View Product \u2192<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\u00c9quipement corollaire<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Optimized chromatography columns designed to pair with Biopure AF resin.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Colonne de la classe Jacked<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Temperature-controlled chromatography with double-layer glass design for precise process conditions during virus purification.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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View Details \u2192<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Colonne de chromatographie \u00e0 basse pression<\/a><\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Reliable low-pressure glass column for laboratory and pilot-scale virus purification with Biopure AF perfusion resin.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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View Details \u2192<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Frequently Asked Questions<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Everything you need to know about Biopure AF perfusion chromatography resin.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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What is perfusion chromatography and how does it differ from gel filtration? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Perfusion chromatography uses particles with large throughpores (3000\u20136000\u00c5) that allow part of the mobile phase to flow directly through the microsphere, creating convective mass transfer. Traditional gel filtration relies entirely on diffusion to transport biomolecules into pores. This convective mechanism enables perfusion resins to maintain high resolution at 2\u20133\u00d7 the throughput of conventional fast-flow gels.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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How does the throughpore \/ porous structure enable high flow rate? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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The large throughpores (3000\u20136000\u00c5) allow part of the mobile phase to flow through the particle, quickly carrying biomolecules to smaller diffusive pores where binding occurs. This reduces the diffusion path and mass transfer resistance. Combined with flexible tentacle structures, the resin achieves linear flow rates up to 1000\u00a0cm\/h at low backpressure without sacrificing binding capacity.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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What are the advantages of the tentacle structure? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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The flexible tentacle structure extends functional groups or ligands away from the particle surface on polymer chains, minimizing steric hindrance between the ligand and target molecules. This improves ligand accessibility and binding capacity, resulting in more effective capture and higher total recovery compared to traditional surface-bonded media.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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What particle size and pore size ranges are available? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Biopure AF resin features 70\u00a0\u00b5m particle size with 3000\u20136000\u00c5 throughpores. The broader Biovanix PSDVB and PMMA platform also offers 45\u201390\u00a0\u00b5m particle sizes and pore sizes from 100\u00a0nm to 400\u00a0nm for customized separation needs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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What is the dynamic binding capacity? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Biopure AF has a dynamic binding capacity (DBC) of 100\u00a0mg lysozyme per ml of resin, maintained even at high flow rates thanks to the efficient convective mass transfer through the throughpore structure.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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What flow rate and backpressure can I expect? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Biopure AF supports linear flow rates up to 1000\u00a0cm\/h at 20\u00b0C with buffer viscosity equivalent to water, at less than 3\u00a0bar (43.5\u00a0psi) backpressure with a 20\u00a0cm column bed height. The rigid PS\/DVB skeleton ensures minimal shrinkage or expansion during mobile phase changes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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What is the pH operating range and chemical stability? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Biopure AF is stable across the full pH range of 1\u201314. The rigid polymeric PS\/DVB particle backbone coated with a proprietary hydrophilic polymer provides excellent chemical stability, tolerating 0.5\u20131M NaOH, organic solvents, and high-salt solvents for cleaning and sanitization.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Can Biopure AF be used for both live and inactivated virus purification? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Yes. Biopure AF features high selectivity with similar affinity to both live and inactivated capsular viruses. The closed-column operation ensures safety and sterility throughout the purification process.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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What are the CIP and storage conditions? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Clean-in-Place (CIP) conditions include 0.5\u20131M NaOH, organic solvents, and high-salt solvents. Storage conditions are 2\u20138\u00b0C in 20% ethanol (EtOH).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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Which viruses and antigens has this resin been applied to? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Biopure AF has been applied to purify Rabies, Influenza, Japanese Encephalitis, Feline Leukemia, Feline Herpes, Feline Calicivirus, Respiratory Syncytial Virus, Human Herpes Simplex, and Human Measles viruses, as well as Human Parainfluenza. Viral and microbial antigens include Herpes Simplex gA and gB Glycoprotein Subunits, Hepatitis B Surface Antigen, Filamentous Hemagglutinin from B.\u00a0pertussis, and Leucocytosis Promoting Factor Hemagglutinin. A validated\u00a0one-step purification protocol for live attenuated rabies virus vaccine<\/a>\u00a0is available.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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How does Biopure AF relate to InertShell product lines? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Biopure AF is part of the VirCap series as a perfusion affinity resin specifically designed for capsular virus capture. InertShell is a separate PMMA core-shell technology product optimized for inactivated virus flow-through purification. The two product lines can be used together in an integrated capture-and-polish workflow.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t

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What chromatography columns and equipment pair well with Biopure AF resin? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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Biopure AF is compatible with Biovanix\u00a0Jacketed Double-layer Glass Columns<\/a>,\u00a0Low-pressure Chromatography Columns<\/a>,\u00a0Syst\u00e8me de remplissage de colonne HPLC Isoplex<\/a>, stainless steel column tubes, and protective pre-columns.\u00a0Contact Biovanix<\/a>\u00a0for personalized equipment recommendations based on your scale and process requirements.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Optimize Your Virus Purification Process<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Contact Biovanix to discuss your specific application, request sample quantities, or get a detailed quote for Biopure AF perfusion chromatography resin.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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    \n\t\t\t <\/ul>\n <\/div>","protected":false},"excerpt":{"rendered":"

    Biopure AF Perfusion Chromatography Resin Biovanix Biopure AF is a rigid, hydrophilic PS-DVB perfusion chromatography resin with 3000\u20136000\u00c5 throughpores and flexible tentacle ligands \u2014 designed for high-flow capture of capsular viruses at 1000\u00a0cm\/h with 100\u00a0mg\/ml dynamic binding capacity. Product Specification Get A Quote \u221a 3000\u20136000\u00c5 Throughpores \u221a 100 mg\/ml DBC at High Flow \u221a pH […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-5099","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t