{"id":5133,"date":"2025-02-27T14:38:12","date_gmt":"2025-02-27T14:38:12","guid":{"rendered":"https:\/\/biovanix.com\/?p=5133"},"modified":"2025-02-27T15:00:52","modified_gmt":"2025-02-27T15:00:52","slug":"purification-en-une-etape-dun-vaccin-vivant-attenue-contre-le-virus-de-la-rage","status":"publish","type":"post","link":"https:\/\/biovanix.com\/fr\/purification-en-une-etape-dun-vaccin-vivant-attenue-contre-le-virus-de-la-rage\/","title":{"rendered":"Purification en une \u00e9tape d'un vaccin vivant att\u00e9nu\u00e9 contre le virus de la rage"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"5133\" class=\"elementor elementor-5133\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c72fc52 e-flex e-con-boxed e-con e-parent\" data-id=\"c72fc52\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b0a4716 elementor-widget elementor-widget-heading\" data-id=\"b0a4716\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Purification en une \u00e9tape d'un vaccin vivant att\u00e9nu\u00e9 contre le virus de la rage<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-02ded2e elementor-widget elementor-widget-text-editor\" data-id=\"02ded2e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La rage est une maladie virale \u00e9vitable qui se transmet le plus souvent par la morsure d'un animal enrag\u00e9. Le virus de la rage infecte le syst\u00e8me nerveux central des mammif\u00e8res, provoquant \u00e0 terme une maladie du cerveau et la mort (<a href=\"https:\/\/www.cdc.gov\/rabies\/about.html\">CDC<\/a>). Dans 99% des cas, les chiens domestiques sont responsables de la transmission du virus de la rage \u00e0 l'homme. Cependant, la rage peut toucher aussi bien les animaux domestiques que les animaux sauvages. Elle se transmet \u00e0 l'homme par morsure ou griffure, g\u00e9n\u00e9ralement par la salive. Sans vaccin antirabique, le taux de mortalit\u00e9 est proche de 100% lorsque les humains et les animaux domestiques sont infect\u00e9s. (<a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/rabies\">Organisation mondiale de la sant\u00e9<\/a>). Les vaccins contre la rage sont la m\u00e9thode la plus efficace pour prot\u00e9ger les humains et les animaux domestiques lorsqu'ils sont expos\u00e9s.<\/p><p>Par rapport \u00e0 la purification traditionnelle du vaccin contre la rage (s\u00e9paration par membrane et exclusion de taille), le milieu Biopure AF de Biovanix peut purifier le virus de la rage vivant att\u00e9nu\u00e9 en une seule \u00e9tape, avec une meilleure r\u00e9cup\u00e9ration des prot\u00e9ines virales et une plus grande puret\u00e9.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7a4790f e-flex e-con-boxed e-con e-parent\" data-id=\"7a4790f\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dd7ccf0 elementor-widget elementor-widget-text-editor\" data-id=\"dd7ccf0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>Tests de purification du vaccin antirabique<\/h2><h3>R\u00e9sultat<\/h3><ul><li>R\u00e9cup\u00e9ration &gt; 80%<\/li><li>Puret\u00e9 &gt; 90%<\/li><li>Taux d'\u00e9limination des impuret\u00e9s &gt; 99%<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-94a9f8d e-flex e-con-boxed e-con e-parent\" data-id=\"94a9f8d\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c71e931 e-con-full e-flex e-con e-child\" data-id=\"c71e931\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e52b74a elementor-widget elementor-widget-text-editor\" data-id=\"e52b74a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Condition d'essai :<\/b><\/p><ul><li>Colonne :  Colonne VirCap\u00ae AF 1ml pr\u00e9-conditionn\u00e9e<\/li><li>Phase mobile A : PB 10mM pH7.4<\/li><li>Phase mobile B : PB 10mM pH7.4 NaCl 2M<\/li><li>D\u00e9bit : 0,5 ml\/min<\/li><li>Test : UV 280nm<\/li><li>\u00c9chantillon : Milieu viral clarifi\u00e9<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f851655 e-con-full e-flex e-con e-child\" data-id=\"f851655\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a8953a8 elementor-widget elementor-widget-image\" data-id=\"a8953a8\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"300\" height=\"174\" src=\"https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/biopure-perfusion-chromatography-AF-application-1-300x174.jpg\" class=\"attachment-medium size-medium wp-image-5118\" alt=\"\" srcset=\"https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/biopure-perfusion-chromatography-AF-application-1-300x174.jpg 300w, https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/biopure-perfusion-chromatography-AF-application-1-768x444.jpg 768w, https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/biopure-perfusion-chromatography-AF-application-1-600x347.jpg 600w, https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/biopure-perfusion-chromatography-AF-application-1.jpg 800w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2a32318 e-flex e-con-boxed e-con e-parent\" data-id=\"2a32318\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-95f020d elementor-widget elementor-widget-text-editor\" data-id=\"95f020d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>En utilisant l'analyse HPSEC pour les tests de la solution d'\u00e9chantillon, du liquide de percolation et du liquide de collecte, et aucun pic de la cible dans le breakthough \u00e0 RT=10min. Le milieu Biopure AF \u00e9lue les particules de virus en changeant la force ionique dans la phase mobile. La puret\u00e9 et la concentration du virus s'am\u00e9liorent de mani\u00e8re significative.<\/p><p>Des tests parall\u00e8les de l'analyse HPSEC pour la collecte des pics cibles sont \u00e9galement effectu\u00e9s par les concurrents.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-37c9f2e e-flex e-con-boxed e-con e-parent\" data-id=\"37c9f2e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0918eb5 e-con-full e-flex e-con e-child\" data-id=\"0918eb5\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cda7b79 elementor-widget elementor-widget-image\" data-id=\"cda7b79\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"169\" height=\"300\" src=\"https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/biovanix-one-step-purification-169x300.jpg\" class=\"attachment-medium size-medium wp-image-5134\" alt=\"\" srcset=\"https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/biovanix-one-step-purification-169x300.jpg 169w, https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/biovanix-one-step-purification.jpg 338w\" sizes=\"(max-width: 169px) 100vw, 169px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-db14fdc e-con-full e-flex e-con e-child\" data-id=\"db14fdc\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-94d95b0 elementor-widget elementor-widget-image\" data-id=\"94d95b0\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"300\" height=\"181\" src=\"https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/biovanix-one-step-purification-1-300x181.jpg\" class=\"attachment-medium size-medium wp-image-5135\" alt=\"\" srcset=\"https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/biovanix-one-step-purification-1-300x181.jpg 300w, https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/biovanix-one-step-purification-1-768x463.jpg 768w, https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/biovanix-one-step-purification-1-600x362.jpg 600w, https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/biovanix-one-step-purification-1.jpg 800w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a85ce24 e-flex e-con-boxed e-con e-parent\" data-id=\"a85ce24\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d57dad7 elementor-widget elementor-widget-text-editor\" data-id=\"d57dad7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"fl-module fl-module-rich-text fl-node-5e68a113ddd36\" data-node=\"5e68a113ddd36\"><div class=\"fl-module-content fl-node-content\"><div class=\"fl-rich-text\"><h2><b>CIP et apurement<\/b><\/h2><p>La fr\u00e9quence des nettoyages en place (NEP) d\u00e9pend des propri\u00e9t\u00e9s et des conditions du solvant.<\/p><p>Pour l'\u00e9tape de capture, nous supposons qu'il faut au moins 30 minutes de NEP \u00e0 contre-courant avec du NaOH 1 M apr\u00e8s chaque passage.<\/p><p>Pour r\u00e9duire la contamination microbienne dans la colonne pr\u00e9emball\u00e9e, nettoyer avec 0,5 \u00e0 1,0 M NaOH, un temps de contact de 1 h est recommand\u00e9.<\/p><\/div><\/div><\/div><div class=\"fl-module fl-module-rich-text fl-node-609b908faae17\" data-node=\"609b908faae17\"><div class=\"fl-module-content fl-node-content\"><div class=\"fl-rich-text\"><h3>Une autre m\u00e9thode de purification du virus de la rage<\/h3><p><a href=\"http:\/\/galaklc.com\/chromatography-purification-of-inactive-rabies-virus\/\">Purification par chromatographie du virus de la rage inactif<\/a><\/p><\/div><\/div><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>One-step Purification For Live Attenuated Rabies Virus Vaccine Rabies is a preventable viral disease most often transmitted through the bite of a rabid animal. The rabies virus infects the central nervous system of mammals, ultimately causing disease in the brain and death (CDC). In up to 99% of cases, domestic dogs are responsible for rabies [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_uag_custom_page_level_css":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5133","post","type-post","status-publish","format-standard","hentry","category-blog"],"aioseo_notices":[],"jetpack_featured_media_url":"","uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"trp-custom-language-flag":false,"woocommerce_thumbnail":false,"woocommerce_single":false,"woocommerce_gallery_thumbnail":false},"uagb_author_info":{"display_name":"biovanix.com","author_link":"https:\/\/biovanix.com\/fr\/author\/biovanix-com\/"},"uagb_comment_info":0,"uagb_excerpt":"One-step Purification For Live Attenuated Rabies Virus Vaccine Rabies is a preventable viral disease most often transmitted through the bite of a rabid animal. The rabies virus infects the central nervous system of mammals, ultimately causing disease in the brain and death (CDC). In up to 99% of cases, domestic dogs are responsible for rabies\u2026","aioseo_head":"\n\t\t<!-- All in One SEO Pro 4.9.3 - aioseo.com -->\n\t<meta name=\"description\" content=\"One-step Purification For Live Attenuated Rabies Virus Vaccine Rabies is a preventable viral disease most often transmitted through the bite of a rabid animal. The rabies virus infects the central nervous system of mammals, ultimately causing disease in the brain and death (CDC). 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