{"id":4850,"date":"2025-02-07T16:33:04","date_gmt":"2025-02-07T16:33:04","guid":{"rendered":"https:\/\/biovanix.com\/?page_id=4850"},"modified":"2025-02-07T17:07:49","modified_gmt":"2025-02-07T17:07:49","slug":"smb-chromatography-system","status":"publish","type":"page","link":"https:\/\/biovanix.com\/ko\/smb-chromatography-system\/","title":{"rendered":"SMB \ud06c\ub85c\ub9c8\ud1a0\uadf8\ub798\ud53c \uc2dc\uc2a4\ud15c"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"4850\" class=\"elementor elementor-4850\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-00aa59d e-flex e-con-boxed e-con e-parent\" data-id=\"00aa59d\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e9a7521 e-con-full e-flex e-con e-child\" data-id=\"e9a7521\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b54dd4b elementor-widget elementor-widget-heading\" data-id=\"b54dd4b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">SMB (Simulated Moving Bed) Chromatography System<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ee1fb51 elementor-widget elementor-widget-heading\" data-id=\"ee1fb51\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Innovative Solutions for Efficient Separation<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2840fce e-con-full e-flex e-con e-child\" data-id=\"2840fce\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7d1af1c elementor-widget elementor-widget-text-editor\" data-id=\"7d1af1c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Biovanix SMB (Simulated Moving Bed) Chromatography System is an advanced continuous chromatography separation technology widely used in chemical, pharmaceutical, and food industries. By simulating the movement of the stationary phase, the SMB system achieves highly efficient and stable separation effects, significantly improving production efficiency and product quality.<\/p><p>Biovanix SMB system connects multiple chromatography columns into a loop system, divided into functional zones such as adsorption, elution, and regeneration. By periodically switching valves, the stationary phase is made to \u201cmove\u201d relative to the mobile phase, achieving continuous sample injection, separation, and collection.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-674d9c6 e-con-full e-flex e-con e-child\" data-id=\"674d9c6\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2eb1fbe elementor-widget elementor-widget-image\" data-id=\"2eb1fbe\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/Continuous-System-300x300.jpg\" class=\"attachment-medium size-medium wp-image-4857\" alt=\"\" srcset=\"https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/Continuous-System-300x300.jpg 300w, https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/Continuous-System-1024x1024.jpg 1024w, https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/Continuous-System-150x150.jpg 150w, https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/Continuous-System-768x768.jpg 768w, https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/Continuous-System-600x600.jpg 600w, https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/Continuous-System-100x100.jpg 100w, https:\/\/biovanix.com\/wp-content\/uploads\/2025\/02\/Continuous-System.jpg 1500w\" sizes=\"(max-width: 300px) 100vw, 300px\" title=\"Continuous-System | BioVanix\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6c1c68e e-flex e-con-boxed e-con e-parent\" data-id=\"6c1c68e\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-4626371 e-con-full e-flex e-con e-child\" data-id=\"4626371\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-36a7ec3 elementor-widget elementor-widget-heading\" data-id=\"36a7ec3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">\uc7a5\uc810<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ec3be9 elementor-widget elementor-widget-text-editor\" data-id=\"3ec3be9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3 class=\"paragraph\"><strong>High Efficiency<\/strong><\/h3><div class=\"paragraph\">The SMB system can increase production efficiency by 3-8 times compared to traditional single-column chromatography.<\/div><h3 class=\"paragraph\"><strong class=\"\">Low Solvent Consumption<\/strong><\/h3><div class=\"paragraph\">Optimized separation processes reduce solvent usage by 20-50%.<\/div><h3 class=\"paragraph\"><strong class=\"\">High Purity and High Recovery Rate<\/strong><\/h3><div class=\"paragraph\">Product purity can reach nearly 100%, with a recovery rate of up to 100%.<\/div><h3 class=\"paragraph\"><strong class=\"\">Continuous Operation<\/strong><\/h3><div class=\"paragraph\">Achieves 24\/7 uninterrupted operation, reducing labor costs.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bd33e9a e-flex e-con-boxed e-con e-parent\" data-id=\"bd33e9a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f8d69f8 elementor-widget elementor-widget-heading\" data-id=\"f8d69f8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Technical Specification<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7507946 elementor-widget elementor-widget-text-editor\" data-id=\"7507946\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"paragraph\"><strong>Number of Columns<\/strong>\uff1a4-12.<\/div><div><strong>Number of DAC Columns<\/strong>\uff1a2-4.<\/div><div class=\"paragraph\"><strong>Flow Rate Range<\/strong>\uff1a0.1-10 L\/min.<\/div><div class=\"paragraph\"><strong>Operating Pressure<\/strong>\uff1a0.1-10 MPa.<\/div><div class=\"paragraph\"><strong>Temperature Range<\/strong>\uff1a5-80\u00b0C.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-94da1e3 elementor-widget elementor-widget-heading\" data-id=\"94da1e3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\uc0ac\uc6a9\uc790 \uc9c0\uc815<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9effccf elementor-widget elementor-widget-text-editor\" data-id=\"9effccf\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We offer comprehensive technical support and services, including system installation, commissioning, training, and after-sales maintenance, to ensure that customers can operate the SMB system smoothly.<\/p><h3 class=\"\"><strong>1. Separation Efficiency<\/strong><\/h3><ul><li><div class=\"paragraph\"><strong>Purity<\/strong>: SMB chromatography is designed to achieve high-purity separation, with product purity often reaching above 99%.<\/div><\/li><li><div class=\"paragraph\"><strong>Recovery Rate<\/strong>: With optimized operating conditions, the recovery rate in SMB chromatography can approach 100%.<\/div><\/li><\/ul><h3 class=\"\"><strong>2. Operating Parameters<\/strong><\/h3><ul><li><div class=\"paragraph\"><strong>\uc720\ub7c9<\/strong>: The flow rate of the mobile phase is a critical parameter, typically optimized based on the separation target. The flow rate range is generally between 0.1-10 L\/min.<\/div><\/li><li><div class=\"paragraph\"><strong>Switching Time<\/strong>: The valve switching time is an important operational parameter in SMB systems, determining the &#8220;movement&#8221; speed of the stationary phase relative to the mobile phase. The selection of switching time needs to be optimized based on the adsorption characteristics of the substances being separated.<\/div><\/li><li><div class=\"paragraph\"><strong>Feed Rate<\/strong>: The amount of feed introduced into the system directly affects separation efficiency and the system&#8217;s production capacity.<\/div><\/li><\/ul><h3 class=\"\"><strong class=\"\">3. System Configuration<\/strong><\/h3><ul><li><div class=\"paragraph\"><strong>Number of Columns<\/strong>: SMB systems typically consist of 4-12 chromatographic columns.<\/div><\/li><li><div class=\"paragraph\"><strong>Column Dimensions<\/strong>: Including column length, diameter, and packing volume, these parameters influence separation effectiveness and the system&#8217;s processing capacity.<\/div><\/li><\/ul><h3 class=\"\"><strong class=\"\">4. Economic Indicators<\/strong><\/h3><ul><li><div class=\"paragraph\"><strong>Solvent Consumption<\/strong>: Compared to traditional batch chromatography, SMB chromatography can reduce solvent usage by 20-50%.<\/div><\/li><li><div class=\"paragraph\"><strong>Adsorbent Usage<\/strong>: SMB chromatography can save up to 50% of adsorbent.<\/div><\/li><li><div class=\"paragraph\"><strong>Operating Cost<\/strong>: Long-term operating costs can be reduced by 50%, primarily due to the savings in solvent and adsorbent usage.<\/div><\/li><\/ul><h3 class=\"\"><strong class=\"\">5. Control and Optimization<\/strong><\/h3><ul><li><div class=\"paragraph\"><strong>Control Strategy<\/strong>: Modern SMB systems often employ advanced control strategies, such as Model Predictive Control (MPC) and Moving Horizon Estimation (MHE), to achieve efficient separation.<\/div><\/li><li><div class=\"paragraph\"><strong>Optimization Parameters<\/strong>: These include isotherm models, mass transfer resistances, and cycle switching times.<\/div><\/li><\/ul><h3 class=\"\"><strong class=\"\">6. Other Indicators<\/strong><\/h3><ul><li><div class=\"paragraph\"><strong>Temperature Range<\/strong>: Typically between 5-80\u00b0C, depending on the nature of the substances being separated.<\/div><\/li><li><div class=\"paragraph\"><strong>Pressure Range<\/strong>: Operating pressure is generally between 0.1-10 MPa.<\/div><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3ad3686 e-flex e-con-boxed e-con e-parent\" data-id=\"3ad3686\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e98a91c elementor-widget elementor-widget-heading\" data-id=\"e98a91c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\uc560\ud50c\ub9ac\ucf00\uc774\uc158<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-79ec215 elementor-widget elementor-widget-text-editor\" data-id=\"79ec215\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3 class=\"paragraph\"><strong>Chemical Industry<\/strong><\/h3><div class=\"paragraph\">Separation of xylene isomers.<\/div><h3 class=\"paragraph\"><strong>Pharmaceutical Industry<\/strong><\/h3><div class=\"paragraph\">Chiral drug separation.<\/div><h3 class=\"paragraph\"><strong>Food Industry<\/strong><\/h3><div class=\"paragraph\">Separation of fructose and glucose.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d7b7bc2 e-flex e-con-boxed e-con e-parent\" data-id=\"d7b7bc2\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-276a3b4 e-con-full e-flex e-con e-child\" data-id=\"276a3b4\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4b10557 elementor-widget elementor-widget-heading\" data-id=\"4b10557\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\uc65c \ubc14\uc774\uc624\ubc14\ub2c9\uc2a4\ub97c \uc120\ud0dd\ud574\uc57c \ud560\uae4c\uc694?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4ff0d9 elementor-widget elementor-widget-text-editor\" data-id=\"a4ff0d9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3>\uc804\ubb38 \uc9c0\uc2dd\uacfc \uacbd\ud5d8<\/h3><div class=\"paragraph\">\uc720\uccb4 \uc774\uc1a1 \uc0b0\uc5c5\uc5d0\uc11c \ub2e4\ub144\uac04\uc758 \uacbd\ud5d8\uc744 \ubc14\ud0d5\uc73c\ub85c \uace0\uac1d\uc758 \ud2b9\uc815 \uc694\uad6c\uc5d0 \ub9de\ub294 \ucd5c\uc0c1\uc758 \uc194\ub8e8\uc158\uc744 \uc81c\uacf5\ud560 \uc218 \uc788\ub294 \uc804\ubb38 \uc9c0\uc2dd\uacfc \ub178\ud558\uc6b0\ub97c \ubcf4\uc720\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub2f9\uc0ac\uc758 \uc804\ubb38\uac00 \ud300\uc740 \uace0\uac1d\uc758 \uc560\ud50c\ub9ac\ucf00\uc774\uc158\uc5d0 \uc801\ud569\ud55c \ud50c\ub7f0\uc800 \ud38c\ud504\ub97c \uc120\ud0dd\ud558\uace0 \uc131\uacf5\uc801\uc778 \uad6c\ud604\uc744 \ubcf4\uc7a5\ud558\uae30 \uc704\ud574 \ucd5c\uc120\uc744 \ub2e4\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/div><div>\u00a0<\/div><h3>\ud488\uc9c8 \ubc0f \uc2e0\ub8b0\uc131<\/h3><div class=\"paragraph\">\ub2f9\uc0ac\ub294 \ucd5c\uace0 \ud488\uc9c8\uc758 \uc81c\ud488\uacfc \uc11c\ube44\uc2a4\ub97c \uc81c\uacf5\ud558\uae30 \uc704\ud574 \ucd5c\uc120\uc744 \ub2e4\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub2f9\uc0ac\uc758 \ud50c\ub7f0\uc800 \ud38c\ud504\ub294 \ucd5c\uace0 \uc218\uc900\uc73c\ub85c \uc124\uacc4 \ubc0f \uc81c\uc870\ub418\uc5b4 \uc2e0\ub8b0\ud560 \uc218 \uc788\ub294 \uc131\ub2a5\uacfc \uc624\ub798 \uc9c0\uc18d\ub418\ub294 \ub0b4\uad6c\uc131\uc744 \ubcf4\uc7a5\ud569\ub2c8\ub2e4.<\/div><div>\u00a0<\/div><h3>\uace0\uac1d \uc9c0\uc6d0<\/h3><div class=\"paragraph\">At [Your Company Name], we believe that customer satisfaction is our top priority. Our dedicated customer support team is always available to assist you with any questions or issues you may have. From technical support to after-sales service, we are here to ensure that you have a smooth and hassle-free experience.<\/div><div>\u00a0<\/div><h3>\ub9de\ucda4\ud615 \uc194\ub8e8\uc158<\/h3><div class=\"paragraph\">\ubaa8\ub4e0 \uc560\ud50c\ub9ac\ucf00\uc774\uc158\uc774 \uace0\uc720\ud558\ub2e4\ub294 \uac83\uc744 \uc798 \uc54c\uace0 \uc788\uae30 \ub54c\ubb38\uc5d0 \uace0\uac1d\uc758 \ud2b9\uc815 \uc694\uad6c\uc0ac\ud56d\uc5d0 \ub9de\ub294 \ub9de\ucda4\ud615 \uc194\ub8e8\uc158\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \ud45c\uc900 \ud50c\ub7f0\uc800 \ud38c\ud504\uac00 \ud544\uc694\ud558\ub4e0 \ub9de\ucda4\ud615 \uc194\ub8e8\uc158\uc774 \ud544\uc694\ud558\ub4e0 \ub2f9\uc0ac\ub294 \uace0\uac1d\uc758 \uc694\uad6c \uc0ac\ud56d\uc744 \ucda9\uc871\ud560 \uc218 \uc788\ub294 \uc5ed\ub7c9\uc744 \uac16\ucd94\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-55e17f7 e-con-full e-flex e-con e-child\" data-id=\"55e17f7\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-35a73f8 elementor-widget elementor-widget-heading\" data-id=\"35a73f8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\ubb38\uc758\ud558\uae30<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4bbd465 elementor-widget elementor-widget-text-editor\" data-id=\"4bbd465\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"paragraph\">\ud50c\ub7f0\uc800 \ud38c\ud504\uc758 \uac15\ub825\ud55c \uc131\ub2a5\uacfc \uc2e0\ub8b0\uc131\uc744 \uacbd\ud5d8\ud560 \uc900\ube44\uac00 \ub418\uc168\ub098\uc694? 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