Supermacroporous Polymer Microspher

In order to address key issues in the purification of viruses and viral particles, Biovanix has always been bold in its exploration of process technology and product development. Its research and production of super macroporous ion exchange chromatography media have achieved precise control over the pore size of the chromatography media. Compared to conventional chromatography media, it has better performance in terms of load capacity and processing speed. It is more conducive to maintaining the structure of viral vectors and viral-like particles.

Advantages

Large molecules or viral particles can easily enter the pores for binding;
The load capacity is more than 10 times that of conventional agarose media and
twice that of conventional polymer media;
It can maintain the integrity of the structure of large molecular proteins, obtaining high yield and high activity of the target protein;
After hydrophilic modification of the microsphere surface and the bonding of ion exchange groups, non-specific adsorption is low, and the degree of mechanization is high;
The molecular mass transfer rate is fast, and better separation can be achieved
at higher flow rates.

Polymer Products

PSDVB Microsphere

PMMA Microsphere

Microsphere Selection

PS-DVB Particle Selection

Product	Poly15 SP	Poly15 Q	Poly30 SP	Poly30 Q
Matrix	Monodisperse PS-DVB
Particle Size	15um		30um
Function Group	(-CH2)SO3-	-CH2N⁺(CH3)3	(-CH2)SO3-	-CH2N⁺(CH3)3
Ligand Density	0.22meq/mL	0.24meq/mL	0.15meq/mL	0.18meq/mL
Capacity	80mg Lys/mL	45mg BSA/mL	60mg Lys/mL	30mg BSA/mL
Flow Rate	150~800cm/h		250~1000cm/h
Max. Pressure	8.0MPa		5.0MPa
pH Stability	2-12
Chemical Stability	All commonly used buffers,1M acetic acid,1M sodium oxychloride, 1M hydrochloric acid, 70% ethanol 30% isopropyl alcohol, 30% acetonitrile, 1%SDS, 6M guanidine hydrochloride, 8M urea, and other commonly used organic solvents; Avoid exposure to strong oxidants.
Usage Temperature	4~30°C
Storage	2~30°C, 20% ethanol

Product	Poly 50M
Matrix	SP	Q	CM	DEAE
Particle Size	PS-DVB
Function Group	50um
Pore Size	100-150nm
Ligand Density	0.15meq/mL	0.16meq/mL	0.15me q/mL	0.16me q/mL
Capacity	>80mgLys	>100mg BSA	>80mgLys	>90mg BSA
Flow Rate	300~1200cm/h
Max Pressure	3.0MPa
pH Stability	1-12
Chemical Stability	All commonly used buffers, 1M acetic acid, 1M sodium oxychloride, 1M hydrochloric acid, 70% ethanol 30% isopropyl alcohol, 30% acetonitrile, 1%SDS, 6M guanidine hydrochloride, 8M urea and other commonly used organic solvents; Avoid exposure to strong oxidants.
Usage Temperature	4~30°C
Storage	2~30°C, 20% ethanol

Product	Poly 50G
Matrix	SP	SP	SP	SP
Particle Size	PS-DVB
Function Group	50um
Pore Size	150-300nm
Ligand Density	0.14me q/mL	0.14me q/mL	0.14me q/mL	0.14me q/mL
Capacity	>70mg Lys	>70mg Lys	>70mg Lys	>70mg Lys
Flow Rate	300~1200cm/h
Max Pressure	2.0MPa
pH Stability	1-12
Chemical Stability	All commonly used buffers, 1M acetic acid, 1M sodium oxychloride, 1M hydrochloric acid, 70% ethanol 30% isopropyl alcohol, 30% acetonitrile, 1%SDS, 6M guanidine hydrochloride, 8M urea and other commonly used organic solvents; Avoid exposure to strong oxidants.
Usage Temperature	4~30°C
Storage	2~30°C, 20% ethanol

Product	Poly 50V
Matrix	SP	SP	SP	SP
Particle Size	PS-DVB
Function Group	50um
Pore Size	300-400nm
Ligand Density	0.12me q/mL	0.12me q/mL	0.12me q/mL	0.12me q/mL
Capacity	>70mg Lys	>70mg Lys	>70mg Lys	>70mg Lys
Flow Rate	300~1200cm/h
Max Pressure	1.0MPa
pH Stability	1-12
Chemical Stability	All commonly used buffers, 1M acetic acid, 1M sodium oxychloride, 1M hydrochloric acid, 70% ethanol 30% isopropyl alcohol, 30% acetonitrile, 1%SDS, 6M guanidine hydrochloride, 8M urea and other commonly used organic solvents; Avoid exposure to strong oxidants.
Usage Temperature	4~30°C
Storage	2~30°C, 20% ethanol

PMMA Particle Selection

Product	PM 70S
Matrix	SP	Q	CM	DEAE
Particle Size	PMMA
Function Group	70um
Pore Size	100nm
Ligand Density	0.18 meq/mL	0.12meq/mL	0.21meq/mL	0.15meq/mL
Capacity	115 mg Lys	80mg BSA	105 mg Lys	80mg BSA
Flow Rate	150~750cm/h
Max Pressure	1.0MPa
pH Stability	2-12
Chemical Stability	All commonly used buffers, 1M acetic acid, 1M sodium oxychloride, 1M hydrochloric acid, 70% ethanol 30% isopropyl alcohol, 30% acetonitrile, 1%SDS, 6M guanidine hydrochloride, 8M urea and other commonly used organic solvents; Avoid exposure to strong oxidants.
Usage Temperature	4~30°C
Storage	2~30°C, 20% ethanol

Product	PM 70M
Matrix	SP	Q	CM	DEAE
Particle Size	PMMA
Function Group	70um
Pore Size	100-150nm
Ligand Density	0.15meq/mL	0.12m eq/mL	0.22meq/ mL	0.11meq/mL
Capacity	115 mg Lys	80m g BSA	105mg Lys	80mg BSA
Flow Rate	150~750cm/h
Max Pressure	0.8MPa
pH Stability	2-12
Chemical Stability	All commonly used buffers, 1M acetic acid, 1M sodium oxychloride, 1M hydrochloric acid, 70% ethanol 30% isopropyl alcohol, 30% acetonitrile, 1%SDS, 6M guanidine hydrochloride, 8M urea and other commonly used organic solvents; Avoid exposure to strong oxidants.
Usage Temperature	4~30°C
Storage	2~30°C, 20% ethanol

Product	PM 70G
Matrix	SP	Q	CM	DEAE
Particle Size	PMMA
Function Group	70um
Pore Size	150-300nm
Ligand Density	0.11meq/mL	0.12meq/mL	0.10meq/mL	0.09meq/mL
Capacity	＞ 70mg Lys	＞ 75mg BSA	＞ 70mg Lys	＞ 60mg BSA
Flow Rate	150~750cm/h
Max Pressure	0.5MPa
pH Stability	2-12
Chemical Stability	All commonly used buffers, 1M acetic acid, 1M sodium oxychloride, 1M hydrochloric acid, 70% ethanol 30% isopropyl alcohol,30% acetonitrile, 1%SDS, 6M guanidine hydrochloride, 8M urea and other commonly used organic solvents; Avoid exposure to strong oxidants.
Usage Temperature	4~30°C
Storage	2~30°C, 20% ethanol

Product	PM 70G
Matrix	SP	Q	CM	DEAE
Particle Size	PMMA
Function Group	70um
Pore Size	150-300nm
Ligand Density	0.11meq/mL	0.12meq/mL	0.10meq/mL	0.09meq/ mL
Capacity	＞ 70mg Lys	＞ 75mg BSA	＞ 70m g Lys	＞ 60mg BSA
Flow Rate	150~750cm/h
Max Pressure	0.5MPa
pH Stability	2-12
Chemical Stability	All commonly used buffers, 1M acetic acid, 1M sodium oxychloride, 1M hydrochloric acid, 70% ethanol 30% isopropyl alcohol,30% acetonitrile, 1%SDS, 6M guanidine hydrochloride, 8M urea and other commonly used organic solvents; Avoid exposure to strong oxidants.
Usage Temperature	4~30°C
Storage	2~30°C, 20% ethanol

Product	PM 70V
Matrix	SP	Q	CM	DEAE
Particle Size	PMMA
Function Group	70um
Pore Size	300-400nm
Ligand Density	0.11meq/mL	0.12meq/mL	0.10meq/mL	0.09meq/ mL
Capacity	＞ 70mg Lys	＞ 75mg BSA	＞ 70m g Lys	＞ 60mg BSA
Flow Rate	150~750cm/h
Max Pressure	0.5MPa
pH Stability	2-12
Chemical Stability	All commonly used buffers, 1M acetic acid, 1M sodium oxychloride, 1M hydrochloric acid, 70% ethanol 30% isopropyl alcohol,30% acetonitrile, 1%SDS, 6M guanidine hydrochloride, 8M urea and other commonly used organic solvents; Avoid exposure to strong oxidants.
Usage Temperature	4~30°C
Storage	2~30°C, 20% ethanol