BioVanix DNA RP HPLC Column

BioVanix DNA RP HPLC Column is a family of high-performance, strong anion-exchange columns designed for separating oligonucleotides. Its column technology involves the creation of a hydrophilic quaternary amino functional layer on the surface of monodispersed, nonporous, spherical PS/DVB particles, in combination with a well-established column packing process.

During oligonucleotide synthesis, it is unavoidable to produce impurities with sizes close to target molecules such as
N-1 and N+1. To ensure drug quality, purity analysis is important. In this application, two short-chain oligonucleotides
(20 mer and 21 mer) with one unit difference are separated with baseline resolution (Rs=2.88) on the DNACore 1000
C18 column under IP-RP mode.

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