Isoplex TFF Versatile Tangential Flow Filtration
Achieve Unattended Concentration and Diafiltration Excellence.
Isoplex TFF (Tangential Flow Filtration) System is a high-performance, versatile platform engineered to bring automation, precision, and broad application flexibility to your critical lab-scale and pilot-scale bioseparation tasks. Designed specifically for sample concentration, diafiltration (buffer exchange), cell harvesting, and clarification, the Isoplex system minimizes manual intervention, guarantees optimal process stability, and accelerates your time to results.
Parameter For Isoplex TFF Versatile Tangential Flow Filtration
Adaptive Membrane Packaging | Membrane Packaging | hollow fiber |
Area | 0.1m | ≤0.4m |
Range | 1KD，3KD，5KD，10KD，30KD，50KD，100KD300KD，500KD750KD 0.1um,0.2um，0.45um，0.65um，1um | |
Silicone Tube Model | 19# ID2.4mm * OD5.6mm | 16# ID3.2mm * OD6.4mm |
Feed Flow Rate | 1-160ml/min | 1-240ml/min |
Replenishment Flow Rate | 1-160ml/min | 1-240ml/min |
TMP Range | 0.3-4bar | 0.3-4bar |
Dimension (L*W*H) | 370mm*420mm*520mm | Pressure Measurement Range | 0-4bar |
Silicone Tube Model | 19#、16# | Feed Pump Pressure | 4bar Max. |
Weight | 25KG | Replenishment Pump Pressure | 1bar Max. |
Voltage | 220V/50Hz | Flow Path Pipeline Pressure | 0-4bar |
Power | 150W | Liquid Storage Tank Pressure | 0-0.1bar |
Volume of Liquid Storage Tank | 500ml-5L | Working Temperature | 2-40℃ |
Why Choose Isoplex TFF? Core Benefits Driving Conversion
| Benefit Pillar | Key Advantage | Impact on Your Workflow |
| Operational Versatility | Supports Cassette Packs, Hollow Fiber Modules, & Membrane Adsorbers. | Eliminates the need for multiple systems; adapts to virtually any TFF application or sample type. |
| Unattended Automation | Features automated Endpoint Control, Fluid Addition, and Data Logging. | Frees up researcher time for other critical tasks, enabling reliable overnight or weekend runs. |
| Process Reproducibility | Achieves precise control over TMP, Permeate Flow, and Retentate Volume. | Guarantees consistent yield and quality batch-to-batch, crucial for regulatory compliance. |
| Optimized Efficiency | Intelligent control algorithms adjust flow rate automatically to maximize flux. | Reduces overall processing time and minimizes the risk of product degradation. |
Unlocking Application Flexibility and Control
Isoplex TFF Versatile Tangential Flow Filtration system empowers users with unparalleled flexibility to combine operational modes (concentration, diafiltration, microfiltration, and cleaning) to perfectly match the application and sample requirements.
Comprehensive Operational Support
- Sample Concentration: Rapidly reduces sample volume while recovering target molecules.
- Diafiltration (Buffer Exchange): Efficiently removes salts, solvents, or small impurities by constant volume replacement.
- Cell Harvesting & Clarification: Gentle and effective separation of large particulates and cells from the liquid phase.
- Microfiltration: Precise removal of fine particulates and sterilization preparation.
Intelligent Features for Enhanced Process Control
- Intelligent Control & Flexibility: Allows for the free combination of functions—including concentration, diafiltration, microfiltration, and cleaning—to meet a wide variety of application and sample requirements.
- Advanced Process Control: Process information is easily monitored and managed via a user-friendly touchscreen interface. The system is capable of handling samples with low working volumes and achieving various concentration factors.
- Automatic Flow Regulation: The system automatically adjusts the flow rate based on the Transmembrane Pressure (TMP), ensuring optimal filtration performance and membrane lifespan.
Engineering for Absolute Stability
Conversion is achieved when the user trusts the technology’s ability to maintain critical parameters. The Isoplex TFF system incorporates three powerful control loops to deliver unmatched stability.
1. Constant Retentate Volume Control
- Mechanism: Utilizes a feed pump to automatically introduce replacement fluid (makeup) into the retentate reservoir, compensating for the volume lost as permeate.
- Result: Ensures the retentate volume is held constant during continuous diafiltration, guaranteeing effective and complete buffer exchange.
2. Transmembrane Pressure (TMP) Control
- Mechanism: Automatically controls the TMP by using an electric proportional valve to adjust the pressure at the retentate and/or permeate outlet.
- Result: Maintains a stable flow rate during concentration and diafiltration, which maximizes flux and achieves the shortest processing time without compromising the membrane.
3. Permeate Flow Control (Microfiltration Focus)
- Mechanism: Employs a precise scale/balance on the permeate side to actively maintain the permeate flow at a user-defined setpoint.
- Result: Prevents uncontrolled flow, which typically leads to premature membrane fouling. This guarantees more stable flux, results in higher protein yield, and achieves shorter overall processing times compared to conventional methods.
Intuitive Operation & Data Integrity
User-Friendly Touchscreen Interface
The main operating screen provides real-time display and monitoring of all key process parameters:
- Flow Rate, Pressure, and Weight (real-time display).
- Current Status of the Fluid Path.
- Complete control over the device’s operational status.
Automated Endpoint Control & Data Logging
The integrated alarm function enables reliable, unattended operation.
- Endpoint Control: Pumps and processes automatically stop when pre-set parameters (e.g., retentate reservoir level or target concentration) are reached.
- Data Logging: All TMP values, flow rates, volumes, and operational statuses are continuously logged, providing comprehensive records for GMP compliance and seamless process validation.
Ready to Transform Your Bioseparation Process?
Stop compromising precision for throughput. The Isoplex TFF System provides the intelligent automation and versatility required to handle your most challenging bioprocessing applications with confidence.
More customization service for your biochemical process:
- TFF System for Protein Concentration
- Automated Tangential Flow Filtration Equipment
- Diafiltration Buffer Exchange System
- TFF System with TMP Control
- High-Yield Cell Harvesting System
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