Isoplex TFF Tangential Flow Filtration System

Achieve Unprecedented Purity and Recovery

Isoplex TFF Tangential Flow Filtration System delivers superior efficiency and maximum product recovery, setting the new standard for pilot and production-scale separation of therapeutic proteins, mAbs, and vaccines.

System Parameter

System Parameter	Manual TFF System	Automated TFF System
Membrane Type	Available: Hollow Fiber, Ultrafiltration Cassette, Ceramic Membrane, Nanofiltration Membrane	Available: Hollow Fiber, Ultrafiltration Cassette, Ceramic Membrane, Nanofiltration Membrane
Membrane Area Range	0.5 – 80 m²	0.5 – 80 m²
Feed Pump Type	Available: Peristaltic Pump, Diaphragm Pump, Centrifugal Pump	Available: Peristaltic Pump, Diaphragm Pump, Centrifugal Pump
Pressure Measurement	Pressure Gauge	Pressure Sensor
Flow Meter	Available (Optional)	Available (Optional)
Conductivity	Available (Optional)	Available (Optional)
pH	Available (Optional): pH 1-14	Available (Optional): pH 1-14
UV Detection	Available (Optional)	Available (Optional)
Integrity Test	Available (Optional)	Available (Optional)
Prefilter	Available (Optional)	Available (Optional)
CIP (Cleaning In Place)	Available (Optional)
SIP (Sterilization In Place)	Available (Optional)	Available (Optional)
Ultrafiltration Tank	Available (Optional)	Available (Optional)
Makeup/Diafiltration Pump	Available: Peristaltic Pump, Diaphragm Pump, Centrifugal Pump	Available: Peristaltic Pump, Diaphragm Pump, Centrifugal Pump
Clamping Device	Available: 0.5 m² (holds 1-5 or 1-10 units), 2.5 m² (holds 1-5 or 1-10 units)	Available: 0.5 m² (holds 1-5 or 1-10 units), 2.5 m² (holds 1-5 or 1-10 units)

Maximize Yield and Accelerate Scale-Up

The separation and purification of high-value biologics demand precision, scalability, and regulatory compliance. The Isoplex TFF System is engineered to meet these critical needs, seamlessly facilitating the journey from laboratory development to large-scale commercial manufacturing. Our core design ensures an extremely low hold-up volume, which is crucial for achieving maximum volume concentration and optimal product recovery, significantly boosting your overall process performance.

Ideal for Critical Biologic Separations:

Monoclonal Antibodies (mAbs)
Vaccines and Plasma
Therapeutic Proteins
Other High-Value Biologics

Choose Your Control: Manual Simplicity or Full Automation

Isoplex TFF System is offered in two versatile series to perfectly match your operational complexity and budget.

Feature	Manual Series	Automated Series
Control Level	User-Convenience and Simplicity	Comprehensive, Hands-Free Control
Operational Scope	Streamlined Operation	Complex Process Execution
Key Automated Components	Manual Operation	Tanks, Detectors, and Pumps
Best For	Routine, Simpler Processes	High-Throughput, Complex Process Control

Maximize Efficiency

The Automated Series provides full integration, allowing for design optimization and component integration that results in a minimal dead volume and ensures maximum product recovery in pre-clinical and clinical scales.

Key Features Driving Bioprocessing Excellence

1. Scalability & Modularity

Our standardized, modular design allows for unique system configurations perfectly matched to specific process requirements.

Cost Efficiency: Minimize initial investment.
Consistency: Simplify consistent production and adherence to cGMP standards.

2. Maximized TFF Performance

The system is designed to maximize TFF performance across all critical operating modes:

Fed-Batch
Concentration
Full Recirculation
Single-Pass Operation

3. Multiple High-Sensitivity Detectors

Ensure real-time process monitoring and control with highly sensitive in-line detectors:

Pression
UV Absorbance
pH
Conductivity

4. Regulatory-Compliant Software

The intuitive software platform ensures user-friendly operation and process security.

Compliance: Fully FDA 21 CFR Part 11 compliant.
Control: User-defined processes and customizable alarm setpoints.

5. Ergonomic and Service-Ready Design

The ergonomic structural design ensures simple operation and easy maintenance, supported by our comprehensive service team.

Service Guarantee: Extensive service support for rapid system implementation and performance optimization.

Full Customization to Fit Your Unique Process

We understand that every biologic process is unique. Built upon the highly flexible Isoplex TFF membrane filtration platform, the Isoplex System can be fully customized according to your specific client requirements, ensuring a tailored solution that integrates seamlessly into your facility.

Ready to Optimize Your Biologic Purification?

Elevate your process yield and ensure regulatory compliance with the industry-leading Isoplex TFF System.

📞 Don’t compromise on product recovery.