Isoplex Membrane Filtration System

High-Efficiency Tangential Flow Filtration for Biologic Purification

Isoplex TFF Membrane Filtration System is employed for the separation and purification of critical biologics, including monoclonal antibodies (mAbs), vaccines, plasma, and therapeutic proteins. It is ideally suited for both pilot-scale and production-scale applications, facilitating the rapid and efficient scale-up of operations from small to large volumes. The system is engineered with an exceptionally low hold-up volume to ensure maximum volume concentration and optimal product recovery, thereby significantly enhancing overall process performance.

Parameter For Isoplex Membrane Filtration System

Produkt	Isoplex TFF 3	Isoplex TFF 5	Isoplex TFF 7	Isoplex TFF 10	Isoplex TFF 14	Isoplex TFF 20
Membrane Area	3m²	5m²	7m²	10m²	14m²	20m²

The Solution for Critical Biologic Processing

In the demanding world of bioprocessing, achieving high product yield while maintaining regulatory compliance and operational efficiency is paramount.

Die Isoplex™ TFF Membrane Filtration System is expertly engineered for the separation and purification of your most critical biologics, including:

Monoclonal Antibodies (mAbs)
Vaccines
Plasma Fractions
Therapeutic Proteins

Designed with an exceptionally low hold-up volume, the Isoplex system guarantees maximum volume concentration and optimal product recovery, directly translating to enhanced overall process performance and profitability.

Why Choose Isoplex

Benefit	Impact on Your Operation
🥇 Maximum Product Recovery	Minimal Dead Volume: Optimized component integration ensures an exceptionally low hold-up volume, maximizing your valuable product yield.
⬆️ Seamless Scalability	Pilot to Production: Facilitates rapid and efficient operations scale-up from small volumes (pilot-scale) to large volumes (production-scale).
✅ cGMP & Regulatory Assurance	Full Process Automation: Consistent, repeatable production simplifies the path to meeting stringent cGMP and FDA 21 CFR Part 11 standards.
💰 Optimized Investment	Standardized Modular Options: Unique system configurations precisely meet process requirements, minimizing unnecessary upfront capital expenditure.

Engineered for Performance: Core Product Features

1. High Recovery & Optimized Design

The system’s proprietary, integrated design focuses on minimizing dead volume. This results in maximum volume concentration and the highest possible product recovery rate—a crucial factor for high-value biopharmaceuticals.

2. Versatile & Flexible Operation Modes

Maximize your Tangential Flow Filtration (TFF) performance with the flexibility to adapt to various process requirements:

Concentration
Full Recirculation
Fed-Batch
Single-Pass Filtration (SPF)

3. Advanced Monitoring and Process Control

Ensure batch consistency and data integrity with comprehensive real-time monitoring:

Multiple high-sensitivity in-line detectors are standard.
Monitoring options for critical parameters, including: Pressure, UV Absorbance, pH, and Conductivity.

4. Regulatory Compliant Software Platform

The intuitive, user-friendly software platform is built for today’s rigorous regulatory environment:

FDA 21 CFR Part 11 Compliant
Intuitive Operating Interface
User-Defined Processes
Customizable Alarm Setpoints for enhanced security and control.

5. Ergonomics and Comprehensive Support

The ergonomic structural design ensures simple operation and easy maintenance, minimizing downtime. Our comprehensive support services guarantee rapid equipment implementation and continuous performance optimization.

Customization: Tailored to Your Specific Requirements

We recognize that no two bioprocessing operations are identical. Based on the high adaptability of the Isoplex TFF membrane filtration platform, the system can be highly customized to meet your specific operational needs, flow rates, and volume targets.

👉 Contact our engineers today to design a system optimized for your unique application.

Ready to maximize your biologic yield and simplify your scale-up process?

Similar Systems for Membrane Filtration System

Tangential Flow Filtration
Biologic Purification
Monoclonal Antibody Purification
Vaccine Manufacturing
Therapeutic Protein Separation
cGMP TFF System
Low Hold-up Volume
High Product Recovery
Pilot-scale TFF
Production-scale TFF

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